Optimized diffusion MRI protocols for estimating axon diameter with known fibre orientation
نویسندگان
چکیده
T. Schneider, H. Lundell, T. B. Dyrby, D. C. Alexander, and C. A. Wheeler-Kingshott NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, Department of Excercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark, Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom
منابع مشابه
In-Vivo Estimates of Axonal Characteristics Using Optimized Diffusion MRI Protocols for Single Fibre Orientation
This work presents diffusion MR protocols that allow estimation of axonal parameters like diameter and density in the live human brain. Previous approaches demand very high field experimental systems or suffer from long acquisition times and are therefore impractical for use in clinical studies. We propose a method that significantly reduces scan time by making use of the a-priori known fibre o...
متن کاملContrast and stability of the axon diameter index from microstructure imaging with diffusion MRI
The ActiveAx technique fits the minimal model of white matter diffusion to diffusion MRI data acquired using optimized protocols that provide orientationally invariant indices of axon diameter and density. We investigated how limitations of the available maximal gradient strength (Gmax) on a scanner influence the sensitivity to a range of axon diameters. Multishell high-angular-diffusion-imagin...
متن کاملAxon Diameter Mapping in the Presence of Orientation Dispersion with Diffusion MRI
Direct measurement of tissue microstructure with diffusion MRI offers a new class of markers, such as axon diameters, that give more specific information about tissue than measures derived from diffusion tensor imaging. The existing techniques of this kind assume a single axon orientation in the tissue model, which may be a reasonable approximation only for the most coherently oriented brain wh...
متن کاملDiffusion Microscopist Simulator
Diffusion magnetic resonance imaging (dMRI) has made a significant breakthrough in neurological disorders and brain research thanks to its exquisite sensitivity to tissue cytoarchitecture. However, as the water diffusion process in neuronal tissues is a complex biophysical phenomena at molecular scale, it is difficult to infer tissue microscopic characteristics on a voxel scale from dMRI data. ...
متن کاملThe impact of gradient strength on in vivo diffusion MRI estimates of axon diameter
Diffusion magnetic resonance imaging (MRI) methods for axon diameter mapping benefit from higher maximum gradient strengths than are currently available on commercial human scanners. Using a dedicated high-gradient 3T human MRI scanner with a maximum gradient strength of 300 mT/m, we systematically studied the effect of gradient strength on in vivo axon diameter and density estimates in the hum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009